Dopaminergic neurons arise from progenitor cells in the ventral midbrain under the coordinated influence of morphogens such as Sonic Hedgehog, Wnt and FGF, and the action of transcription factors ...

Leuven, 7 August 2024—The mechanisms underlying intellectual disabilities or autism remain largely unknown. Researchers in the labs of Prof. Pierre Vanderhaeghen and Prof. Vincent Bonin at the VIB-KU ...

A new study in zebrafish reveals that the gene nexmifb—a paralog of the human neurodevelopmental gene NEXMIF—plays a critical role in spinal motor neuron development by modulating the axon guidance ...

The mechanisms underlying intellectual disabilities or autism remain largely unknown. Researchers in the labs of Prof. Pierre Vanderhaeghen and Prof. Vincent Bonin at the VIB-KU Leuven Center for ...

The study builds on decades of research into dopaminergic neuron development and Parkinson's disease led by the late Prof. Ernest Arenas. His work laid important foundations for understanding how ...

Study reveals how proteins direct nerve cell precursors to turn into specialized neurons. Brain development is a highly orchestrated process involving numerous parallel and sequential steps. Many of ...

For decades, scientists have been searching for better ways to treat diseases that slowly destroy the brain. Conditions such ...

Subscribe to our newsletter for the latest sci-tech news updates. The researchers also identified a second progenitor cell type that supports dopaminergic neuron development and survival. Dopaminergic ...

During brain development, neurons can regulate their movement until they reach their final destination thanks to a "molecular switch" involving the protein Teneurin 4 (Ten4). This protein can guide ...

The distinct aging rates of neural progenitor cells and Wnt signaling dictate mammalian cortical layer proportions.